Vor Biopharma
Market cap $1.22B 61.4M shares (10-Q, Oct 26, 2026) × $19.88 close Nov 6, 2026
Most recent annual filing: 2026-03-15
- telitacicept Ph3 topline1H 2027telitacicept Ph3 topline, 1H 2027, thesis-defining
- UPSTREAM MG Ph3 topline1H 2027UPSTREAM MG Ph3 topline, 1H 2027, major
- UPSTREAM oMG pivotal start1H 2027UPSTREAM oMG pivotal start, 1H 2027, routine
Bar width shows how precise the guidance is — a pin is a stated date, a wide band a six-month window. Deeper blue means more of the thesis rides on the event; it is not a view on the stock.
Pipeline (2 active programs)
Discontinued (4)
- tremtelectogene empogeditemcel — Acute Myeloid Leukemia · winddown of prior clinical and manufacturing operations announced May 8, 2025; IP sold in August/September 2025
- tremtelectogene empogeditemcel — Myelodysplastic Syndrome · winddown of prior clinical and manufacturing operations announced May 8, 2025; IP sold in August/September 2025
- VCAR33 — Acute Myeloid Leukemia · winddown of prior clinical and manufacturing operations announced May 8, 2025; IP sold in August/September 2025
- VADC45 — undisclosed · winddown of prior clinical and manufacturing operations; IP sold in August/September 2025
Capital (as filed)
- Cash
- $79.0M cash and cash equivalents · Sep 30, 2026 (10-Q)
- Short-term investments
- $403M Sep 30, 2026
- Operating cash flow
- −$32.7M quarter Jun 30, 2026 → Sep 30, 2026, year-to-date difference (10-Q)
- As stated in coverage
- $482M cash, runway early 2029 per the update of Oct 30, 2026 — the company's own words as read there, not the filed figure
Offering documents (2)
- 2026-10-30 424B5 · At-the-market program up to $150M
- 2026-09-04 S-3ASR · Shelf registration
Cash, investments and operating cash flow are the company's own XBRL facts as filed with the SEC, each shown with its period end and tag. As-stated figures come from the company's own words as read in Biotech Distilled coverage, dated, and routinely count securities and planned financing that a balance sheet does not. Offering rows are the SEC cover pages as filed. Not investment advice. Figures as of Nov 7, 2026.
Biotech Distilled coverage (10)
- 2026-10-30 UPDATE: Vor Bio (VOR) - The ATM Gets Reloaded 🔒 Paid
- 2026-10-23 UPDATE: Vor Bio (VOR) - The Kidney Clock Nearly Stops 🔒 Paid
- 2026-09-09 UPDATE: Vor Bio (VOR) - The Enrollment Clock Stops 🔒 Paid
- 2026-08-12 UPDATE: Vor Bio (VOR) - They Sold Into the Rip 🔒 Paid
- 2026-07-21 UPDATE: Vor Bio (VOR) - RA Answers the Watch Item 🔒 Paid
- 2026-07-07 UPDATE: Vor Bio (VOR) - The Anchor Leaves, the Closer Arrives 🔒 Paid
- 2026-06-08 UPDATE: Vor Bio (VOR) - The Free Look Pays Off Twice
- 2026-05-15 UPDATE: Vor Bio (VOR) - NEJM Stamps the Free Look 🔒 Paid
- 2026-04-27 UPDATE: Vor Bio (VOR) - The Anchor is Selling 🔒 Paid
- 2026-04-06 Vor Bio (VOR) - Scientific Deep Dive Fortelitacicept and Pipeline Products 🔒 Paid
Articles open on Substack. Some are subscriber-only; those marked ★ Distilled Pro are for Distilled Pro members.
Verdict history (10 calls)
Every verdict Biotech Distilled has published on Vor Biopharma, oldest first — the full history, never a selection. How calls are scored: the track record.
- 2026-04-06 Watch Vor Bio (VOR) - Scientific Deep Dive Fortelitacicept and Pipeline Products Dual BAFF/APRIL inhibition is scientifically compelling but the 2028 composition-of-matter patent cliff, CMC tech-transfer risk, and demographic-translation uncertainty warrant waiting for execution proof before committing capital.
- 2026-04-27 Watch UPDATE: Vor Bio (VOR) - The Anchor is Selling RA Capital's aggressive 53% reduction in directly-held common is a meaningful downgrade to the 'smart money backing the pivot' bull-case pillar, warranting continued sideline positioning until the conviction signal re-clarifies.
- 2026-05-15 Speculative buy speculative UPDATE: Vor Bio (VOR) - NEJM Stamps the Free Look NEJM publication of TELIGAN Phase 3 with 55% placebo-adjusted proteinuria reduction and eGFR preservation materially de-risks the dual BAFF/APRIL biology and makes the pipeline-in-a-product narrative investable, while the RA Capital trim now reads more like portfolio sizing than a negative signal.
- 2026-06-08 Speculative buy speculative UPDATE: Vor Bio (VOR) - The Free Look Pays Off Twice Two simultaneous NMPA approvals (IgAN and SjD) give telitacicept five approved indications in China on one molecule, further de-risking the pipeline-in-a-product narrative while the stock has weakened 11.8% on no negative news, widening the fundamental-to-price gap.
- 2026-07-07 Speculative buy speculative UPDATE: Vor Bio (VOR) - The Anchor Leaves, the Closer Arrives Levin's board resignation removes the last 'still committed' governance signal from RA Capital, but Zaccardelli's appointment — a CEO with three strategic exits including a $10B Merck deal — sharpens the M&A exit optionality and adds manufacturing expertise directly relevant to the CMC tech-transfer risk.
- 2026-07-21 Speculative buy speculative UPDATE: Vor Bio (VOR) - RA Answers the Watch Item RA Capital's conversion of 2.1M pre-funded warrants into common stock — the mirror image of April's selling — shifts the RA read from bearish-at-governance-level to ambiguous, modestly cleaning up the conviction picture without changing the underlying binary.
- 2026-08-12 Speculative buy speculative UPDATE: Vor Bio (VOR) - They Sold Into the Rip Management's $48.9M July ATM raise at $19.11 confirms dilution appetite rather than a dilution gap, while enrollment remains on track and commercial build-out spending corroborates the exit-optionality thesis; watchers should note the asymmetry has compressed at $23.59.
- 2026-09-09 Speculative buy speculative UPDATE: Vor Bio (VOR) - The Enrollment Clock Stops UPSTREAM MG is fully enrolled and the 1H27 readout is now arithmetic rather than guidance, retiring enrollment slippage risk, while a second registrational oMG trial is added; the demographic-translation risk remains the sole unanswered question.
- 2026-10-23 Speculative buy speculative UPDATE: Vor Bio (VOR) - The Kidney Clock Nearly Stops Two-year TELIGAN data showing eGFR slope of -0.6 vs -5.7 and 89% reduction in hard progression events represents the strongest hard-endpoint validation of dual BAFF/APRIL biology to date, while the 24.5% stock pullback from September highs to near the July ATM price may warrant a fresh look at the spread to the gMG binary.
- 2026-10-30 Speculative buy speculative UPDATE: Vor Bio (VOR) - The ATM Gets Reloaded A fresh $150M ATM facility (up to ~11.7% potential dilution) confirms management's appetite to sell into strength ahead of the 1H27 binary, but the balance sheet doesn't need the cash and the clinical timeline remains locked, so the thesis is intact with a new supply overhang that may cap rallies into the readout.
- Long call · opened May 15, 2026 at $14.63 · +35.9% vs XBI +16.5% (Nov 6, 2026)
Every verdict Biotech Distilled has published on this company, in order, with the post it came from — the full history, never a selection. Position figures are the same ones shown on /track-record, computed by the same method. Editorial opinion, not investment advice.
Timing, in the company's words (3 quotes from 2 filings)
Sentences quoted verbatim from the company's SEC filings, newest filing first. Each sits under the filing it appeared in; the "matched to" tag names the calendar row it was read for.
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“Topline data from the trial is anticipated in the first half of 2027.”
matched to UPSTREAM MG · topline data · read as first half of 2027 -
“Based on our current operating plan, we expect that our cash, cash equivalents and marketable securities will enable us to fund our operating expenses and capital expenditure requirements into early 2029.”
matched to telitacicept · topline data · read as early 2029
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“Topline data from the trial is anticipated in the first half of 2027.”
matched to telitacicept · topline data · read as first half of 2027
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Timing sentences quoted from the company's own SEC filings, each under the filing it appeared in. The 'matched to' tag is the calendar row the sentence was read for; the filing is the source. Not investment advice.
Filings & releases (32)
SEC filings from EDGAR and press releases captured from the company's investor-relations site, newest first. Releases captured from May 13, 2026; filings from March 2026. Summaries come from the BD update that read the document; "BD extracted" counts point at the pipeline table above. All companies →
- Oct 30, 2026ReleaseVor Bio Reports Third Quarter 2026 Financial Results and Provides Corporate Update→ BD updateSummary on the 10-QBD extracted 1 program update from this document → VOR pipeline
- Oct 30, 2026424B5Prospectus supplement (offering)→ BD updateSummary on the 10-Q
- Oct 30, 202610-QQuarterly report→ BD updateVor Bio's Q3 print confirms enrollment is locked, the 48-week Chinese gMG data adds an MSE durability layer (42.1%, ~83% of follow-up in remission), and management wasted no time refreshing the ATM with a new $150M facility — exactly the watch item flagged in the August update.
- Oct 22, 2026ReleaseTelitacicept Demonstrates Durable Preservation of Kidney Function Through Two Years in Phase 3 TELIGAN Trial in IgA Nephropathy→ BD updateTELIGAN's two-year final analysis just delivered what the May NEJM interim promised: hard kidney-function preservation with an eGFR slope near zero (-0.6 vs -5.7 mL/min/1.73m²/year, p<0.001) and an 89% relative risk reduction in clinically meaningful eGFR decline — presented in the plenary session at ASN Kidney Week, while the stock sits 24.5% below the September enrollment-completion update.
- Sep 29, 2026ReleaseTelitacicept Demonstrates Deep and Durable Minimal Symptom Expression Through 48 Weeks in Generalized Myasthenia GravisA post hoc 48-week analysis from RemeGen's Chinese Phase 3 shows 94%+ of gMG patients hitting ≥5-point MG-ADL improvement and 86.7% of minimal-symptom responses sustained month-to-month — yet the stock has shed 27% since enrollment closed three weeks ago, a disconnect that demands decoding.BD extracted 1 program update from this document → VOR pipeline
- Sep 8, 2026ReleaseVor Completes Enrollment of Global Phase 3 UPSTREAM MG Trial and Expands Telitacicept Global Franchise into Ocular Myasthenia Gravis→ BD updateUPSTREAM MG enrollment is complete — the operational execution risk is retired, the 1H27 readout clock is officially set, and Vor just announced a new oMG registrational program that widens the pipeline-in-a-product footprint before the binary lands.
- Sep 4, 2026S-3ASRAutomatic shelf registration
- Sep 1, 2026ReleaseVor Bio To Participate in Upcoming September Conferences
- Aug 11, 2026ReleaseVor Bio Reports Second Quarter 2026 Financial Results and Provides Corporate Update
- Aug 11, 202610-QQuarterly report
- Jul 21, 2026SCHEDULE 13D/A13D amendment
- Jul 7, 2026ReleaseVor Bio Appoints David Zaccardelli to Board of Directors
- Jul 7, 20268-KCurrent report: officer / director change
- Jun 12, 20268-KCurrent report: shareholder vote
- Jun 8, 2026ReleaseTelitacicept Receives NMPA Approval for the Treatment of Sjögren’s Disease in ChinaBD extracted 1 program update from this document → VOR pipeline
- Jun 8, 2026ReleaseTelitacicept Receives NMPA Conditional Approval for the Treatment of IgA Nephropathy in China
- Jun 8, 20268-KCurrent report: Reg FD disclosure · EX-99.1
- May 28, 2026ReleaseVor Bio to Participate in the 2026 Jefferies Global Healthcare Conference
- May 14, 2026ReleaseVor Bio Announces Publication of Interim Analysis of TELIGAN, a China Phase 3 Trial of Telitacicept in IgA Nephropathy, in The New England Journal of Medicine
- May 13, 2026ReleaseVor Bio Reports First Quarter 2026 Financial Results and Provides Corporate Update
- May 13, 202610-QQuarterly report
- Apr 27, 2026S-3Shelf registration
- Apr 27, 2026DEFA14AProxy soliciting material
- Apr 27, 2026DEF 14AProxy statement
- Apr 21, 2026SCHEDULE 13D/A13D amendment
- Apr 15, 2026SCHEDULE 13D/A13D amendment
- Apr 10, 2026SCHEDULE 13D/A13D amendment
- Apr 8, 2026SCHEDULE 13D/A13D amendment
- Apr 1, 2026SCHEDULE 13D/A13D amendment
- Mar 30, 202610-KAnnual report
- Mar 27, 20268-KCurrent report: material agreement, unregistered sale of equity, Reg FD disclosure · EX-99.1
- Mar 16, 2026SCHEDULE 13D/A13D amendment
17 more filings (13G holder notices, S-8, proxy material, SEC correspondence …)
- Nov 5, 2026SCHEDULE 13G/A13G amendment
- Aug 14, 2026SCHEDULE 13G/A13G amendment
- Aug 14, 2026SCHEDULE 13G/A13G amendment
- Aug 13, 2026SCHEDULE 13G/A13G amendment
- Aug 7, 2026SCHEDULE 13G/A13G amendment
- Aug 6, 2026SCHEDULE 13GPassive >5% holder (13G)
- Jul 30, 2026SCHEDULE 13GPassive >5% holder (13G)
- May 15, 2026SCHEDULE 13G/A13G amendment
- May 15, 2026SCHEDULE 13G/A13G amendment
- May 6, 2026SCHEDULE 13G/A13G amendment
- May 6, 2026SCHEDULE 13G/A13G amendment
- May 6, 2026EFFECTRegistration effective
- May 4, 2026CORRESPCORRESP
- May 1, 2026UPLOADUPLOAD
- Apr 27, 2026ARSAnnual report to shareholders
- Apr 1, 2026SCHEDULE 13GPassive >5% holder (13G)
- Mar 30, 2026S-8Employee plan registration