ADC Therapeutics
Market cap $202M 127.7M shares (10-Q, Aug 3, 2026) × $1.58 close Nov 6, 2026
Most recent annual filing: 2026-03-10
- ZYNLONTA + glofitamab toplineDec 2026ZYNLONTA + glofitamab topline, Dec 2026, thesis-defining
- ZYNLONTA monotherapy MZL readoutDec 2026ZYNLONTA monotherapy MZL readout, Dec 2026, material
- LOTIS-7, LOTIS-5, MCL, WM, MZLDec 12–14, 2026LOTIS-7, LOTIS-5, MCL, WM, MZL, Dec 12–14, 2026, routine
- ZYNLONTA corporate update1H 2027ZYNLONTA corporate update, 1H 2027, notable
- ZYNLONTA + rituximab FL readout2Q 2027ZYNLONTA + rituximab FL readout, 2Q 2027, material
Bar width shows how precise the guidance is — a pin is a stated date, a wide band a six-month window. Deeper blue means more of the thesis rides on the event; it is not a view on the stock.
Pipeline (5 active programs)
ZYNLONTA
loncastuximab tesirine-lpyl · loncastuximab tesirineZYNLONTA
loncastuximab tesirine-lpylADCT-241
Capital (as filed)
- Cash
- $219M cash and cash equivalents · Jun 30, 2026 (10-Q)
- Operating cash flow
- −$11.8M quarter Mar 31, 2026 → Jun 30, 2026, year-to-date difference (10-Q)
- As stated in coverage
- $189M cash per the update of Nov 4, 2026 — the company's own words as read there, not the filed figure
Cash, investments and operating cash flow are the company's own XBRL facts as filed with the SEC, each shown with its period end and tag. As-stated figures come from the company's own words as read in Biotech Distilled coverage, dated, and routinely count securities and planned financing that a balance sheet does not. Offering rows are the SEC cover pages as filed. Not investment advice. Figures as of Nov 7, 2026.
Biotech Distilled coverage (4)
- 2026-11-05 UPDATE: ADC Therapeutics (ADCT) - The Canary Survived the Doubling 🔒 Paid
- 2026-10-09 UPDATE: ADC Therapeutics (ADCT) - The Capital Stack Gets Rebuilt 🔒 Paid
- 2026-08-14 UPDATE: ADC Therapeutics (ADCT) - The Floor Just Got a Trapdoor 🔒 Paid
- 2026-07-10 ADC Therapeutics (ADCT) — Scientific Deep Dive for ZYNLONTA and the CD19 ADC Pipeline
Articles open on Substack. Some are subscriber-only; those marked ★ Distilled Pro are for Distilled Pro members.
Verdict history (4 calls)
Every verdict Biotech Distilled has published on ADC Therapeutics, oldest first — the full history, never a selection. How calls are scored: the track record.
- 2026-07-10 Watch ADC Therapeutics (ADCT) — Scientific Deep Dive for ZYNLONTA and the CD19 ADC Pipeline Confirmed-PFS 3L+ floor and LOTIS-7 optionality keep it from being a PASS, but flat OS, fatal-tox signal, STARGLO regulatory precedent, and ~$420M capital stack against $167M equity keep it off the buy list until Q4 2026 LOTIS-7 data and sBLA path resolve.
- 2026-08-14 Avoid UPDATE: ADC Therapeutics (ADCT) - The Floor Just Got a Trapdoor FDA raised substantial concerns about LOTIS-5's benefit-risk and the verification of clinical benefit, putting the 3L+ accelerated approval floor formally in play and turning this into a single-asset regulatory binary with leverage.
- 2026-10-09 Watch UPDATE: ADC Therapeutics (ADCT) - The Capital Stack Gets Rebuilt An $86.6M PIPE led by Bain, $70M loan paydown, and elimination of the HCR change-of-control toll largely dismantle the leveraged-binary setup that drove the August downgrade, though the 3L+ label remains contested and dilution has already landed.
- 2026-11-05 Speculative buy speculative UPDATE: ADC Therapeutics (ADCT) - The Canary Survived the Doubling LOTIS-7 response rates held almost unchanged as n doubled to 97 with 79% 12-month CR durability and a far lower fatal-event rate than LOTIS-5, MZL strengthened to 90.8% two-year PFS, and revenue growth turned volume-driven, justifying a lottery-ticket speculative position ahead of the December ASH oral.
- Avoid call · opened Aug 14, 2026 at $1.01 · closed Oct 9, 2026 (downgraded to WATCH from avoid) at $1.73 · +71.3% vs XBI -2.3%
- Long call · opened Nov 5, 2026 at $1.64 · -3.7% vs XBI +2.6% (Nov 6, 2026)
Every verdict Biotech Distilled has published on this company, in order, with the post it came from — the full history, never a selection. Position figures are the same ones shown on /track-record, computed by the same method. Editorial opinion, not investment advice.
Timing, in the company's words (4 quotes from 4 filings)
Sentences quoted verbatim from the company's SEC filings, newest filing first. Each sits under the filing it appeared in; the "matched to" tag names the calendar row it was read for.
-
-
“Met with U.S. FDA in early August 2026”
matched to ZYNLONTA + glofitamab (LOTIS-7) · topline data · read as August 2026
-
-
-
“Met with U.S. FDA in early August 2026”
matched to ZYNLONTA (LOTIS-5, LOTIS-7) · other · read as August 2026 / matched to ZYNLONTA + glofitamab (LOTIS-7) · topline data · read as August 2026 / matched to ZYNLONTA monotherapy (MZL IIT) · readout other · read as August 2026
-
-
-
“The Company is preparing for a scheduled pre-sBLA meeting with the FDA in August 2026 to discuss the potential regulatory path forward for ZYNLONTA in combination with rituximab to treat relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) following the recent topline data results from the Phase 3 LOTIS-5 trial.”
matched to ZYNLONTA + glofitamab (LOTIS-7) · topline data · read as August 2026
-
-
-
“ADC Therapeutics expects to submit an sBLA in the fourth quarter of 2026.”
matched to ZYNLONTA + rituximab (LOTIS-5) · regulatory submission · read as fourth quarter of 2026
-
Timing sentences quoted from the company's own SEC filings, each under the filing it appeared in. The 'matched to' tag is the calendar row the sentence was read for; the filing is the source. Not investment advice.
Filings & releases (26)
SEC filings from EDGAR and press releases captured from the company's investor-relations site, newest first. Releases captured from Aug 6, 2026; filings from March 2026. Summaries come from the BD update that read the document; "BD extracted" counts point at the pipeline table above. All companies →
- Nov 4, 2026ReleaseADC Therapeutics Announces Abstracts at the 68th ASH Annual Meeting Highlighting Breadth of ZYNLONTA® Clinical Program→ BD updateSummary on the 8-K
- Nov 4, 20268-KCurrent report: results of operations, Reg FD disclosure, other events · EX-99.1 EXHIBIT 99.1→ BD updateThe LOTIS-7 abstract data the entire thesis has been waiting for arrived after the close: 88.7% ORR and 75.3% CR across 97 evaluable r/r DLBCL patients, with responses deepening over time and median PFS not reached — and critically, a safety profile that looks far cleaner than LOTIS-5's fatal-infection disaster.
- Nov 3, 2026S-4Merger registration
- Nov 3, 2026ReleaseADC Therapeutics to Present at November Investor Conferences
- Nov 2, 2026ReleaseADC Therapeutics to Announce Third Quarter 2026 Financial Results on November 9, 2026
- Oct 29, 2026ReleaseADC Therapeutics Announces ZYNLONTA® Updates in JapanBD extracted 1 program update from this document → ADCT pipeline
- Oct 13, 20268-KCurrent report: material agreement, results of operations, unregistered sale of equity · EX-99.1 EXHIBIT 99.1
- Oct 8, 2026ReleaseADC Therapeutics Announces Comprehensive Strategic Financial Restructuring Marking Key Capital Structure Improvements→ BD updateADCT just executed a three-part balance sheet overhaul — $86.6M PIPE, term loan cut to $50M with the liquidity covenant eliminated, and the HCR change-of-control payment removed entirely — buying itself runway into 2029 and stripping away the distress-discount logic. The regulatory binary on LOTIS-7 and the 3L+ label is unchanged, but the balance sheet trap I described in August just got materially defused.
- Sep 3, 2026ReleaseADC Therapeutics to Participate in the 2026 Cantor Global Healthcare Conference
- Aug 13, 2026ReleaseADC Therapeutics Reports Second Quarter 2026 Financial Results and Provides Operational UpdatesBD extracted 1 program update from this document → ADCT pipeline
- Aug 13, 20268-KCurrent report: results of operations, Reg FD disclosure · EX-99.1 EXHIBIT 99.1
- Aug 13, 202610-QQuarterly report
- Aug 6, 2026ReleaseADC Therapeutics to Host Second Quarter 2026 Financial Results Conference Call on August 13, 2026
- Jul 2, 20268-KCurrent report: officer / director change
- Jun 24, 20268-KCurrent report: Reg FD disclosure, other events · EX-99.1 EXHIBIT 99.1
- Jun 3, 20268-KCurrent report: Reg FD disclosure, other events · EX-99.1 EXHIBIT 99.1
- Jun 2, 20268-KCurrent report: shareholder vote
- May 4, 20268-KCurrent report: results of operations · EX-99.1
- May 4, 202610-QQuarterly report
- Apr 20, 2026DEFA14AProxy soliciting material
- Apr 20, 2026DEF 14AProxy statement
- Apr 15, 2026424B3Prospectus (resale / update)
- Mar 16, 2026424B3Prospectus (resale / update)
- Mar 10, 2026S-3Shelf registration
- Mar 10, 20268-KCurrent report: results of operations · EX-99.1
- Mar 10, 202610-KAnnual report
11 more filings (13G holder notices, S-8, proxy material, SEC correspondence …)
- Oct 29, 2026SCHEDULE 13GPassive >5% holder (13G)
- Aug 14, 2026SCHEDULE 13GPassive >5% holder (13G)
- Aug 13, 2026S-8Employee plan registration
- Jul 27, 2026SCHEDULE 13GPassive >5% holder (13G)
- Apr 24, 2026SCHEDULE 13G/A13G amendment
- Apr 10, 2026PRE 14APRE 14A
- Apr 6, 2026SCHEDULE 13G/A13G amendment
- Mar 16, 2026EFFECTRegistration effective
- Mar 12, 2026UPLOADUPLOAD
- Mar 12, 2026CORRESPCORRESP
- Mar 10, 2026ARSAnnual report to shareholders