Eloxx Pharmaceuticals
Market cap $50.2M 4.0M shares (10-Q, Aug 7, 2026) × $12.44 close Nov 6, 2026
Most recent annual filing: 2026-03-15
- Exaluren nmADPKD enrollment done2027Exaluren nmADPKD enrollment done, 2027, routine
- Exaluren NMAS toplinemid-2027Exaluren NMAS topline, mid-2027, thesis-defining
- Exaluren NMAS toplineby mid-2027Exaluren NMAS topline, by mid-2027, thesis-defining
Bar width shows how precise the guidance is — a pin is a stated date, a wide band a six-month window. Deeper blue means more of the thesis rides on the event; it is not a view on the stock.
Pipeline (4 active programs)
ZKN-013
Capital (as filed)
- Cash
- $62.0M cash and cash equivalents · Jun 30, 2026 (S-1)
- Operating cash flow
- −$4.8M quarter Mar 31, 2026 → Jun 30, 2026, year-to-date difference (S-1)
- As stated in coverage
- $62.0M cash, runway mid-2028 per the update of Oct 20, 2026 — the company's own words as read there, not the filed figure
Offering documents (1)
- 2026-10-22 424B3 · Resale (selling stockholders)
Cash, investments and operating cash flow are the company's own XBRL facts as filed with the SEC, each shown with its period end and tag. As-stated figures come from the company's own words as read in Biotech Distilled coverage, dated, and routinely count securities and planned financing that a balance sheet does not. Offering rows are the SEC cover pages as filed. Not investment advice. Figures as of Nov 7, 2026.
Biotech Distilled coverage (4)
- 2026-10-20 UPDATE: Eloxx Pharmaceuticals (ELOX) - A Better Endpoint, a Later Date, and a Novartis CMO 🔒 Paid
- 2026-09-11 UPDATE: Eloxx Pharmaceuticals (ELOX) - The Trial Starts, and So Does the Exit Door 🔒 Paid
- 2026-08-12 UPDATE: Eloxx Pharmaceuticals (ELOX) - The Quarter Where the Money Showed Up and the Trial Didn’t 🔒 Paid
- 2026-06-18 Eloxx Pharmaceuticals (ELOX) — Scientific Deep Dive for Exaluren and the Ribosomal Readthrough Pipeline 🔒 Paid
Articles open on Substack. Some are subscriber-only; those marked ★ Distilled Pro are for Distilled Pro members.
Verdict history (4 calls)
Every verdict Biotech Distilled has published on Eloxx Pharmaceuticals, oldest first — the full history, never a selection. How calls are scored: the track record.
- 2026-06-18 Watch Eloxx Pharmaceuticals (ELOX) — Scientific Deep Dive for Exaluren and the Ribosomal Readthrough Pipeline Interesting biology and a newly-solvent balance sheet, but the entire human efficacy case is three patients on an unvalidated surrogate, the readthrough mechanism class is under an FDA/EMA cloud, and the only meaningful catalyst is a year away after a 230% relisting squeeze.
- 2026-08-12 Watch UPDATE: Eloxx Pharmaceuticals (ELOX) - The Quarter Where the Money Showed Up and the Trial Didn't Solvency risk is retired and runway now plausibly covers both 2027 readouts, but the entire efficacy case remains three patients on an unvalidated surrogate with no new human data.
- 2026-09-11 Watch UPDATE: Eloxx Pharmaceuticals (ELOX) - The Trial Starts, and So Does the Exit Door First patients dosed in EXACT retires execution risk but the S-1 converts the warrant overhang into registered sellable stock, and the efficacy case remains n=3 on a surrogate no regulator has validated.
- 2026-10-20 Watch UPDATE: Eloxx Pharmaceuticals (ELOX) - A Better Endpoint, a Later Date, and a Novartis CMO ADPKD program gains a more credible regulatory endpoint (htTKV) and a seasoned CMO, but its readout slipped to 1H 2029 past the funded runway, and the lead Alport asset's efficacy case is still n=3 on an unvalidated surrogate.
Every verdict Biotech Distilled has published on this company, in order, with the post it came from — the full history, never a selection. Position figures are the same ones shown on /track-record, computed by the same method. Editorial opinion, not investment advice.
Timing, in the company's words (1 quote from 1 filing)
Sentences quoted verbatim from the company's SEC filings, newest filing first. Each sits under the filing it appeared in; the "matched to" tag names the calendar row it was read for.
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“We received clearance to proceed with a Phase 2b clinical trial for exaluren in NMAS patients (without kidney biopsies in U.S. pediatric patients) under an IND from the FDA and we plan to initiate this trial in the third quarter of 2026.”
matched to Exaluren (NMAS) · topline data · read as third quarter of 2026
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Timing sentences quoted from the company's own SEC filings, each under the filing it appeared in. The 'matched to' tag is the calendar row the sentence was read for; the filing is the source. Not investment advice.
Filings & releases (19)
SEC filings from EDGAR and press releases captured from the company's investor-relations site, newest first. Releases captured from Aug 12, 2026; filings from March 2026. Summaries come from the BD update that read the document; "BD extracted" counts point at the pipeline table above. All companies →
- Nov 2, 2026ReleaseEloxx Pharmaceuticals to Present at the 3rd Annual Guggenheim Healthcare Innovation Conference
- Oct 29, 2026ReleaseEloxx Pharmaceuticals Announces FDA Clearance of Investigational New Drug Application for Exaluren in Nonsense-Mutation ADPKD
- Oct 22, 20268-KCurrent report: officer / director change, other events
- Oct 22, 2026424B3Prospectus (resale / update)
- Oct 20, 2026ReleaseEloxx Pharmaceuticals Finalizes 52-Week Phase 2 EXPRESS Study Design in Nonsense-Mutation ADPKD and Appoints T.R. Srinivas, M.D., Chief Medical Officer→ BD updateEloxx finalized the EXPRESS Phase 2 design in nonsense-mutation ADPKD — 60 patients, 52 weeks, htTKV primary — with FDA pre-IND feedback flagging htTKV as a potential accelerated-approval surrogate and a Breakthrough Therapy Designation pathway, while simultaneously appointing a Novartis nephrology CMO with direct ADPKD credentials.
- Oct 19, 2026ReleaseEloxx Pharmaceuticals Appoints Biopharmaceutical Industry Veteran Geno Germano to its Board of Directors
- Sep 11, 2026S-1Registration statement→ BD updateThe EXACT Study just dosed its first two patients, confirming the Phase 2b is live — the single operational milestone I told readers to wait for. The stock has cratered -18% from the August close despite the news, and a new S-1 filed today explains part of the pressure.
- Sep 11, 2026ReleaseEloxx Pharmaceuticals Announces First Patients Dosed in Phase 2b EXACT Study of Exaluren in Nonsense Mutation Alport Syndrome→ BD updateSummary on the S-1
- Aug 12, 2026ReleaseEloxx Pharmaceuticals Reports Second Quarter 2026 Financial Results and Provides Business Updatevia aggregator
- Aug 11, 20268-KCurrent report: results of operations · EX-99.1BD extracted 1 program update from this document → ELOX pipeline
- Aug 11, 202610-QQuarterly report
- Jun 9, 2026424B4Prospectus (IPO / follow-on)
- Jun 4, 2026S-1/ARegistration statement (amended)
- Jun 1, 2026S-1/ARegistration statement (amended)
- Jun 1, 20268-KCurrent report: unregistered sale of equity, holder rights modified, officer / director change
- May 7, 2026S-1Registration statement
- May 5, 202610-QQuarterly report
- May 1, 20268-KCurrent report: shareholder vote
- Mar 17, 202610-KAnnual report
19 more filings (13G holder notices, S-8, proxy material, SEC correspondence …)
- Sep 18, 2026EFFECTRegistration effective
- Aug 14, 2026SCHEDULE 13GPassive >5% holder (13G)
- Aug 14, 2026SCHEDULE 13GPassive >5% holder (13G)
- Jul 27, 2026SCHEDULE 13GPassive >5% holder (13G)
- Jun 17, 2026SCHEDULE 13GPassive >5% holder (13G)
- Jun 17, 2026SCHEDULE 13GPassive >5% holder (13G)
- Jun 16, 2026SCHEDULE 13GPassive >5% holder (13G)
- Jun 16, 2026SCHEDULE 13GPassive >5% holder (13G)
- Jun 15, 2026SCHEDULE 13GPassive >5% holder (13G)
- Jun 8, 2026EFFECTRegistration effective
- Jun 8, 2026CERTCERT
- Jun 5, 2026SCHEDULE 13G/A13G amendment
- Jun 1, 20268-A12B8-A12B
- May 29, 2026SCHEDULE 13G/A13G amendment
- May 8, 2026DEF 14CDEF 14C
- May 4, 2026SCHEDULE 13GPassive >5% holder (13G)
- May 1, 2026SCHEDULE 13GPassive >5% holder (13G)
- Apr 28, 2026PRE 14CPRE 14C
- Mar 20, 2026DRSDRS