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AN2 Therapeutics

Market cap $151M 37.7M shares (10-Q, Aug 6, 2026) × $4.00 close Nov 6, 2026

Most recent annual filing: 2026-03-17

Catalyst timeline

11 trackedQuarter catalyst calendar →
  1. AN2-502998 Chagas Ph2 startLate 2026 (guided): Chagas Phase 2 start with DNDiAN2-502998 Chagas Ph2 start, Late 2026 (guided): Chagas Phase 2 start with DNDi, routine
  2. AN2 Therapeutics corporate updateNov 2026AN2 Therapeutics corporate update, Nov 2026, routine
  3. Epetraborole PV interim2027Epetraborole PV interim, 2027, major
  4. Divesiran competitor Ph3 start1H 2027Divesiran competitor Ph3 start, 1H 2027, routine
  5. Silence Therapeutics / Merck KGaA1Q 2027Silence Therapeutics / Merck KGaA, 1Q 2027, routine
  6. PN-8047 Protagonist Ph1 start1Q 2027PN-8047 Protagonist Ph1 start, 1Q 2027, routine
  7. AN2-502998 Chagas Ph2 topline2H 2027AN2-502998 Chagas Ph2 topline, 2H 2027, major
  8. Epetraborole REBOUND toplineLate 2027 (guided): REBOUND toplineEpetraborole REBOUND topline, Late 2027 (guided): REBOUND topline, major
  9. AN2 Therapeutics options repricing corporateSep 19, 2027AN2 Therapeutics options repricing corporate, Sep 19, 2027, routine
  10. Epetraborole PV Ph3 readout~2028Epetraborole PV Ph3 readout, ~2028, notable
  11. Epetraborole composition patent litigation rulingJun 2028Epetraborole composition patent litigation ruling, Jun 2028, routine

Bar width shows how precise the guidance is — a pin is a stated date, a wide band a six-month window. Deeper blue means more of the thesis rides on the event; it is not a view on the stock.

Pipeline (6 active programs)

Technology platforms

Boron Chemistry Platform · GSK

Boron-based small molecule discovery platform enabling high ligand efficiency against difficult or undruggable targets; current focus areas include infectious diseases (Chagas disease, NTM/M. abscessus, melioidosis, tuberculosis) and oncology (ENPP1, PI3Kα solid-tumor targets); has produced first-in-class molecules against CPSF3 and LeuRS targets

Targets: LeuRS, PI3Kα, ENPP1, CPSF3

Boron Chemistry Platform

Boron-based small molecule discovery platform enabling inhibitors against targets considered undruggable or difficult to access with traditional chemistry. Focus areas include infectious diseases (Chagas disease, NTM, melioidosis, tuberculosis) and oncology (ENPP1, PI3Kα). Has produced first-in-class molecules against CPSF3 and LeuRS targets.

Targets: ENPP1, PI3Kα, CPSF3, LeuRS

Boron Chemistry

Boron-based small molecule discovery platform enabling novel binding modes against difficult or undruggable targets; current disease focus includes infectious diseases (NTM, Chagas), hematologic diseases (polycythemia vera), oncology (solid tumors), and bone disorders. Known target classes include CPSF3, LeuRS, ENPP1, and PI3Kα.

Targets: PI3Kα, ENPP1, LeuRS, CPSF3

boron chemistry platform · Gates Foundation

Boron chemistry platform for discovery and development of novel small molecule therapeutics; disease focus spans hematologic diseases, infectious diseases and oncology, including tuberculosis, malaria, melioidosis, and bone disorders.

Capital (as filed)

Cash
$44.3M cash and cash equivalents · Jun 30, 2026 (10-Q)
Short-term investments
$34.1M Jun 30, 2026
Long-term investments
$1.5M Jun 30, 2026
Operating cash flow
−$7.0M quarter Mar 31, 2026 → Jun 30, 2026, year-to-date difference (10-Q)
As stated in coverage
$79.9M cash, runway into 2029 per the deep dive of Oct 26, 2026 — the company's own words as read there, not the filed figure

Cash, investments and operating cash flow are the company's own XBRL facts as filed with the SEC, each shown with its period end and tag. As-stated figures come from the company's own words as read in Biotech Distilled coverage, dated, and routinely count securities and planned financing that a balance sheet does not. Offering rows are the SEC cover pages as filed. Not investment advice. Figures as of Nov 7, 2026.

Biotech Distilled coverage (1)

Articles open on Substack. Some are subscriber-only; those marked ★ Distilled Pro are for Distilled Pro members.

Verdict history (1 call)

Every verdict Biotech Distilled has published on AN2 Therapeutics, oldest first — the full history, never a selection. How calls are scored: the track record.

  1. Watch AN2 Therapeutics (ANTX) - Scientific Deep Dive for Epetraborole and AN2-502998 and Pipeline Products The PV thesis rests on an adverse event in non-PV patients with a controlled hematocrit effect smaller than phlebotomy-dependent patients need and a platelet signal pointing the wrong way; wait for Part 1 PV data before taking a position.

Every verdict Biotech Distilled has published on this company, in order, with the post it came from — the full history, never a selection. Position figures are the same ones shown on /track-record, computed by the same method. Editorial opinion, not investment advice.

Timing, in the company's words (2 quotes from 1 filing)

Sentences quoted verbatim from the company's SEC filings, newest filing first. Each sits under the filing it appeared in; the "matched to" tag names the calendar row it was read for.

Timing sentences quoted from the company's own SEC filings, each under the filing it appeared in. The 'matched to' tag is the calendar row the sentence was read for; the filing is the source. Not investment advice.

Filings & releases (19)

SEC filings from EDGAR and press releases captured from the company's investor-relations site, newest first. Releases captured from Nov 2, 2026; filings from March 2026. Summaries come from the BD update that read the document; "BD extracted" counts point at the pipeline table above. All companies →

11 more filings (13G holder notices, S-8, proxy material, SEC correspondence …)